Pharmaceutical Qib Sibutramine Raw Khoom

1. Suav lub npe: Sibutramine
2. Suav alias: N - (1- (1- (4-chlorophenyl) cyclobutyl) -3-methylbutyl) - N, N-dimethylamine
3. English lub npe: Sibutramine
4. CAS Nr .: 106650-56-0
5. Cov mis mos molecular: C17H26ClN
6. Molecular hnyav: 279.85
7. Qhov tseeb zoo: 279.17500
8. PSA: 3.24000
9.LogP: 4.73800
Lub cev thiab tshuaj muaj zog
1. Cov tsos: Dawb crystalline hmoov
2. Melting point: 191-192℃C
Cov ntaub ntawv molecular
1. Molar refractive index: 83.76
2. Molar ntim (cm3/mol): 271.3
3. Tos Zhang Biarong (90.2K): 670.5
4. Nto nro (dyne/cm): 373.3
5. Polarization tus nqi (10-24cm3): 33.2
6. Ib leeg isotope mass: 279.175378 Da
7. Nominal loj: 279 Da
8. Qhov nruab nrab zoo: 279.848 Da
Xam cov ntaub ntawv tshuaj
1. Tus nqi siv rau hydrophobic parameter xam (XlogP): 5.4
2. Tus naj npawb ntawm cov nyiaj pub dawb hydrogen: 0
3. Tus naj npawb ntawm hydrogen daim ntawv txais nyiaj: 1
4. Number of rotatable chemical bonds: 5
5. Tus naj npawb ntawm tautomers: 0
6. Topological molecular polarity nto thaj tsam: 3.2
7. Tus naj npawb ntawm cov atom hnyav: 19
8. Nto nqi: 0
9. Kev nyuaj siab: 275
10. Tus naj npawb ntawm isotopic atoms: 0
11. Txiav txim seb tus naj npawb ntawm atomic stereocenters: 0
12. Tsis paub tus naj npawb ntawm atomic stereocenters: 1
13. Txiav txim seb tus naj npawb ntawm cov tshuaj stereocenters: 0
14. Tus naj npawb ntawm cov tshuaj tsis muaj tseeb ntawm cov stereocenters: 0
15. Cov ntsiab lus: 99%
16: Kev kuaj xyuas txoj kev: Ua kua theem chromatogram
17: Txee lub neej: 24 lub hlis
18: Txoj kev khaws cia; Khaws rau hauv qhov chaw txias thiab qhuav, deb ntawm lub teeb.

1. hnyav 1g ntawm cov qauv khoom, muab tso rau hauv ib lub raj centrifuge, ntxiv methanol hnyav, sonicate rau 20 feeb, centrifuge ntawm 4000 r / min rau 5 feeb, coj lub supernatant, lim nws los ntawm 0.22 μ m organic lim membrane, thiab tau txais cov tshuaj ntsuam xyuas; Complex matrices tuaj yeem ua kom muaj zog-theem extraction purification thiab tshem tawm matrix cuam tshuam.
2. C18/T3 chromatographic kem yog xaiv raws li cov chromatographic kem; Cov theem txawb yog 0.1% formic acid aqueous tov -0.1% formic acid acetonitrile, nrog gradient elution; Electrospray zoo ion hom ESI +, ntau cov tshuaj tiv thaiv kev soj ntsuam MRM hom, sibutramine yam ntxwv ion khub zoo, sab nraud tus qauv qauv nkhaus txoj kev kom muaj nuj nqis, kev kuaj pom muaj peev xwm ncav cuag qib ng, qhov tseeb siab, tuaj yeem paub qhov txawv tsis zoo.
3. Kev ua haujlwm siab ua kua chromatography (HPLC): C18 thim rov qab theem chromatography kem, nrhiav kom tau wavelength 223nm, methanol buffer ntsev system raws li lub xov tooj ntawm tes, tsim nyog rau cov ntsiab lus txiav txim siab ntawm siab - purity raw khoom kuaj raws li khaws cia lub sij hawm sib piv; Qhov tsis zoo yog qhov kev cuam tshuam ntawm matrix tsis tuaj yeem txiav txim siab tag nrho, thiab cov qauv zoo yuav tsum tau lees paub los ntawm kev tshuaj xyuas huab hwm coj.

1. Dietary capsule formula: Cov khoom no muaj cov hmoov purity siab thiab ruaj khov zoo, thiab tuaj yeem siv rau kev tsim khoom ntawm lub cev tswj cov tshuaj ntsiav tshuaj. Nws yog sib xws nrog ntau yam khoom noj khoom haus excipients thiab haum rau industrial filling txheej txheem.
2. Cov ntsiav tshuaj khoom qab zib txoj kev loj hlob: haum rau kev kho lub cev hnyav, nrog cov hmoov zoo flowability, yooj yim rau kev sib xyaw thiab pellet rau cov ntsiav tshuaj nias, ua tau raws li qhov loj - teev cov khoom noj khoom haus.
3. Khoom noj khoom haus hmoov: tuaj yeem muab ntxiv rau hauv cov txheej txheem kev noj zaub mov zoo, nrog kev sib raug zoo zoo, haum rau cov hmoov sib tov thiab ua tiav, thiab tsom rau kev tswj hwm lub cev txhua hnub.
4. Cov khoom noj khoom haus hla ciam teb: hloov mus rau txawv teb chaws cov qauv kev tshawb fawb thiab kev tsim kho, tuaj yeem muab cov ntaub ntawv ua tiav COA thiab MSDS, ua tau raws li kev tshuaj xyuas thiab tshuaj xyuas, siv rau cov khoom noj khoom haus txawv teb chaws.
5. Cov khoom noj khoom haus sib xyaw ua ke: tuaj yeem ua ke nrog cov nroj tsuag rho tawm thiab cov khoom noj muaj txiaj ntsig zoo rau cov khoom noj khoom haus kho mob kho mob, pab cov khoom lag luam tshiab.

1. 1kg/aluminium foil hnab, ua -hauv ob - txheej PE noo- pov thawj lub hnab, lub tshuab nqus tsev ntim ntim, tsim rau kev sim me me - ntsuas ntsuas thiab ua qauv.
2. 5kg/aluminium foil hnab, noo noo- pov thawj thiab lub teeb pov thawj lub tshuab nqus tsev kaw, yooj yim rau lub Hoobkas kev debugging thiab kuaj me me rau nruab nrab.
3. 25kg / cardboard nruas, ob npaug - txheej PE lined hnab hauv lub nruas, txheem ntim khoom ntim, haum rau loj - nplai hauv tsev.
4. 25kg/UN certified export cardboard nruas, ua tau raws li qhov yuav tsum tau rau kev thauj mus los hauv hiav txwv thiab huab cua, haum rau 40FCL tag nrho cov thawv xa tawm txawv teb chaws.
5. 100g/sample txhuas lub hnab, lub tshuab nqus tsev ntim khoom ywj pheej, siv rau kev kuaj cov neeg siv khoom thiab kev soj ntsuam kev tsim nyog, nrog COA thiab MSDS cov ntaub ntawv txuas nrog cov khoom.

1. Nquag, kaw thiab ya raws - cov ntaub ntawv pov thawj yog siv rau kev thauj mus los, nrog kev tiv thaiv tag nrho ntawm lub teeb thiab noo noo thoob plaws hauv cov txheej txheem los tiv thaiv cov ntaub ntawv nyoos los ntawm kev ntub dej thiab tsis zoo, ua kom cov khoom ruaj khov.
2. Txhawb nqa ntau txoj kev logistics xws li kev thauj mus los hauv av thiab hauv hiav txwv, nws tuaj yeem hloov mus rau kev xa khoom loj hauv tsev thiab txawv teb chaws 40FCL FCL kev lag luam tawm txawv teb chaws.
3. Kev txiav txim xa tawm tuaj yeem ua tiav los ntawm cov txheej txheem kev lis kev cai tshaj tawm txog cov ntaub ntawv, uas yog synchronized nrog cov khoom thiab ua tau raws li cov kev cai ntawm kev soj ntsuam thiab tshuaj xyuas.
4. Kev soj ntsuam nruj me ntsis ntawm kev ntim khoom ua ntej thauj khoom mus rau hauv lub tsheb, ntsuas kev tiv thaiv kom tsis txhob muaj compression thiab txo qhov kev pheej hmoo ntawm kev puas tsuaj thiab xau thaum thauj.
5. Peb tuaj yeem npaj cov kev daws teeb meem raws li cov neeg siv khoom xav tau, muab cov ntaub ntawv taug qab freight, thiab pab cov neeg siv khoom kom nkag siab qhov tiag - lub sijhawm nce ntawm kev thauj khoom.

1. Yog tias lub ntim tau pom tias muaj kev puas tsuaj tom qab tuaj txog, peb yuav muab cov ntaub ntawv pov thawj sai li sai tau thaum peb tau txais cov khoom, thiab peb yuav ceev nrooj xyuas thiab tswj nws kom tiv thaiv cov cai thiab kev txaus siab ntawm peb cov neeg siv khoom.
2. Cov ntaub ntawv nyoos tuaj yeem raug xa mus kuaj xyuas thaum tau txais. Yog tias cov txiaj ntsig kev xeem tsis zoo li COA cov ntaub ntawv qhia tawm los ntawm peb lub tuam txhab, peb txhawb kev sib tham txog kev daws teeb meem.
3. Peb pab pawg kws tshaj lij nyob online los muab kev sib tham txog cov ntaub ntawv siv thev naus laus zis thiab teb cov lus nug ntsig txog kev siv mis.
4. Ua raws li tag nrho cov txheej txheem kev txiav txim, nrog rau kev sib txuas lus tiag tiag ntawm lub sijhawm xa khoom mus rau qhov tau txais, thiab pab sai sai rau kev taug qab txog cov teeb meem logistics uas tshwm sim.
5. Vim muaj teeb meem zoo nrog peb cov ntaub ntawv raw, peb tuaj yeem daws lawv raws li peb daim ntawv cog lus kev koom tes thiab muab kev saib xyuas ua ntej- muag thiab tom qab- kev muag khoom thoob plaws hauv tag nrho cov txheej txheem.

1. Q: Koj puas tuaj yeem lav qhov purity ntawm cov khoom siv raw?
Teb: Qhov purity ntawm cov ntaub ntawv raw yog ruaj khov ntawm ntau dua los yog sib npaug rau 99%, thiab txhua pawg los nrog COA cov ntaub ntawv ntsuam xyuas, uas tuaj yeem pab txhawb thib peb - kev tshuaj xyuas thiab kev txheeb xyuas los ntawm cov neeg siv khoom.
2. Q: Koj puas tuaj yeem muab cov ntaub ntawv MSDS thiab COA ua tiav?
Teb: Yog, tom qab tso qhov kev txiav txim, MSDS cov lus qhia kev nyab xeeb thiab COA cov ntaub ntawv soj ntsuam zoo tuaj yeem muab tau ib txhij kom tau raws li qhov xav tau ntawm kev tshaj tawm kev lis kev cai thiab kev tshawb xyuas lub tsev rau khoom.
3. Q: Qhov kev txiav txim yam tsawg kawg nkaus yog dab tsi thiab peb tuaj yeem muab cov qauv?
Teb: Peb txhawb nqa cov qauv me me thiab muab ob qho tib si me me thiab loj batch loj. Yam tsawg kawg nkaus txiav txim kom muaj nuj nqis tuaj yeem sib tham nrog peb cov neeg ua haujlwm.
4. Q: Dab tsi yog qhov tsos thiab solubility ntawm cov khoom siv raw?
Teb: Cov khoom yog cov hmoov dawb nrog lub cev ruaj khov thiab tshuaj lom neeg. Nws muaj kev sib raug zoo nrog rau feem ntau excipients thiab yog haum rau kev ua nyob rau hauv ntau npaum li cas cov ntaub ntawv.
5. Q: Cov khoom siv davhlau ya nyob twg tsim nyog rau?
Teb: Nws tuaj yeem siv rau cov qauv kev noj qab haus huv loj xws li cov khoom qab zib compressed, tshuaj ntsiav, dej haus, khoom noj khoom haus hmoov, thiab lwm yam. Lub davhlau ya nyob twg yuav tsum ua raws li cov cai hauv zos.
6. Q: Puas yog kev sib xyaw ua ke thiab kev sib xyaw ntawm cov khoom siv raw tuaj yeem ua tiav?
Teb: Peb txhawb customized compounding kev daws teeb meem thiab tuaj yeem muab kev txhawb nqa raws li cov neeg siv khoom xav tau. Peb yuav sib txuas lus thiab ntsuas qhov ua tau ntawm kev daws teeb meem.
7. Q: Puas yog logistics txhawb kev xa tawm? Peb puas tuaj yeem tuav 40FCL tag nrho cov thawv ntim khoom?
Teb: Txhawb nqa kev xa khoom hauv tsev thiab kev lag luam tawm txawv teb chaws, tuaj yeem lees paub tag nrho cov thawv ntim khoom xaj, thiab koom tes los muab cov ntaub ntawv pov thawj tsim nyog.
8. Q: Kuv yuav ua li cas yog tias cov khoom ntub lossis puas thaum lub sijhawm thauj khoom?
Teb: Thov tshawb xyuas lub ntim ntawm qhov chaw thaum tau txais. Yog tias muaj kev puas tsuaj, thov muab cov duab pov thawj, thiab peb yuav muab tag nrho cov nyiaj rov qab.
9. Q: Yuav ua li cas los daws qhov tsis sib xws ntawm cov khoom tau txais kev soj ntsuam thiab daim ntawv tshaj tawm?
Teb: Yog tias muaj qhov tsis sib xws ntawm qhov thib peb -kev xeem thib peb thiab peb daim ntawv tshaj tawm, ob tog tuaj yeem koom ua ke tso cai rau peb lub koom haum thib peb -tog saib xyuas thiab tswj nws raws li daim ntawv cog lus kev koom tes.

Lub tuam txhab cog lus cog lus tias tag nrho cov khoom siv raw khoom muag los ntawm peb lub tuam txhab tau ua raws li kev cai lij choj, nruj me ntsis ua raws li lub teb chaws cov qauv kev tsim khoom thiab kev lag luam thiab kev lag luam ntshuam thiab xa tawm, thiab txiav txim siab tshem tawm tag nrho cov khoom tsis tsim nyog thiab tsis raws cai los ntawm kev tawm hauv lub Hoobkas rau kev ncig. Peb lub tuam txhab tau koom tes nrog kev tshawb fawb thiab tsim cov khoom siv raw khoom siv tau ntau xyoo, nrog cov kev cob qhia tsim khoom thiab ua tiav kev tshuaj xyuas zoo. Los ntawm kev xaiv cov khoom siv raw, kev ua kom huv thiab ua tiav, kev sim cov khoom tiav mus rau kev xa khoom thiab kev xa khoom, peb tau tsim lub kaw - voj tswj mechanism rau tag nrho cov txheej txheem, nruj me ntsis tswj cov chaw soj ntsuam zoo nyob rau hauv txhua theem, thiab xyuas kom meej lub purity, stability, thiab kev nyab xeeb ntawm txhua batch ntawm raw cov ntaub ntawv nyob rau hauv txhua yam.
Tag nrho lub Hoobkas cov ntaub ntawv raw cov ntaub ntawv ua tiav thiab taug qab mus rau qhov chaw, muab cov neeg siv khoom ua tiav cov ntaub ntawv ua raws li COA cov ntaub ntawv soj ntsuam zoo thiab zoo, MSDS kev nyab xeeb cov ntaub ntawv, thiab lwm yam, ua tau raws li ntau yam kev xav tau xws li kev tshawb xyuas khoom hauv tsev, thib peb - tog kuaj, thiab kev lag luam txawv teb chaws kev lis kev cai clearance, thiab ua tiav cov khoom lag luam thiab kev tshawb fawb. Peb lub tuam txhab yeej ib txwm ua raws li kev lag luam lub tswv yim ntawm kev ua haujlwm ncaj ncees thiab ua tau zoo- taw qhia, thiab yuav tsis txhob dag lossis tsis lees paub cov ntaub ntawv tsim nyog.
Yog tias cov ntaub ntawv raw khoom ntws tawm ntawm peb lub tuam txhab raug pom tias muaj qhov zoo, ua raws, lossis lwm yam teeb meem ntsig txog peb lub luag haujlwm tom qab raug kuaj los ntawm cov chaw tso cai, lub tuam txhab yuav teb tam sim ntawd, sib txuas lus thiab txheeb xyuas cov teeb meem, thiab muab cov kev daws tshwj xeeb xws li rov kuaj xyuas, hloov, thiab rov ua dua dawb, tiv thaiv tag nrho cov cai thiab kev txaus siab ntawm txhua tus neeg siv khoom. Nyob rau tib lub sijhawm, peb tshaj tawm hais tias peb lub tuam txhab tsuas yog muab cov kev pabcuam raw khoom raws cai. Downstream cov neeg siv khoom tsim cov qauv tsim, ntim kev txhawb nqa, kev muag khoom lag luam thiab lwm yam yuav tsum nruj me ntsis ua raws li cov cai hauv zos thiab cov kev cai thiab ua raws li cov cai thiab cov cai.

Cim npe nrov: Tuam Tshoj Pharmaceutical Grade Sibutramine raw khoom manufacturers, lwm tus neeg, Hoobkas