Cov ntsiab lus siab Sibutramine Hydrochloride Raw Khoom CAS 84485-00-7

1. Suav lub npe: Sibutramine hydrochloride (monohydrate)
2. English lub npe: Sibutramine Hydrochloride Monohydrate
3. Lub npe tshuaj: 1- (4-}chlorophenyl) - N, N-dimethyl - - (2-methylpropyl) cyclobutane methylamine hydrochloride monohydrate
4. CAS naj npawb: Dawb puag: 106650-56-0 Anhydrous hydrochloride: 84485-00-7 Monohydrate hydrochloride: 125494-59-9
1. Molecular hnyav: 334.33
2. Cov tsos mob: Dawb los yog tawm dawb crystalline hmoov, tsw tsw, saj iab me ntsis
3. Melting point: 191 ~ 192 degree
4. Solubility: soluble hauv methanol, ethanol DMSO; me ntsis soluble hauv dej; Hygroscopic
5. Cia tej yam kev mob: Khaws rau hauv qhov tsaus ntuj, kaw, txias thiab qhuav qhov chaw, noo noo - pov thawj. Nws raug nquahu kom khaws cia rau hauv qhov chaw kaw ntawm 15-25 degree

Sibutramine hydrochloride yog lub hauv paus monoamine reuptake inhibitor thiab cov tshuaj. Nws nkag mus rau tib neeg lub cev thiab yog metabolized los ntawm CYP3A4 nyob rau hauv lub siab los tsim ob active metabolites: N-monodemethylsibutramine (M1) thiab N, N-bisdemethylsibutramine (M2), uas exert pharmacological teebmeem. Lub hauv paus ntsiab lus ntawm kev txiav txim: inhibit presynaptic membrane 5-hydroxytryptamine thiab ua kom cov concentration ntawm neurotransmitters nyob rau hauv lub hauv paus synaptic cleft; Txhim khu satiety, txo qab los noj mov, thiab nce basal zog siv los ua kom poob phaus.
Yam ntxwv: Tsis ncaj qha txhawb kev tso tawm neurotransmitter; Tsis muaj qhov tseem ceeb anticholinergic, antihistamine, lossis MAO inhibitory teebmeem.

Sibutramine hydrochloride monohydrate yog cov hmoov dawb los yog tawm dawb crystalline hmoov, thiab qee cov khoom siv tuaj yeem nthuav tawm cov xim dawb me ntsis uas tsis pom cov xim tsis huv, clumps, pwm, lossis khoom txawv teb chaws. Cov khoom no tsis muaj ntxhiab tsw tshwj xeeb thiab muaj qhov iab me ntsis thaum saj; Lub fineness ntawm crystal hmoov txawv nyob ntawm seb cov txheej txheem ntau lawm. Cov ntaub ntawv raw khoom yog cov hmoov zoo, thiab qee cov txheej txheem ua kom zoo tuaj yeem ua rau cov khoom me me crystalline. Lub flowability ntawm cov hmoov feem ntau yog nruab nrab, thiab me ntsis compaction yuav tshwm sim tom qab ntev - lub sij hawm cia thiab compression. Tom qab maj mam dispersion, hmoov lub xeev tuaj yeem rov qab los. Cov khoom no muaj zog hygroscopicity thiab tuaj yeem nqus dej vapor sai sai thaum raug rau huab cua huab cua siab. Tom qab raug cuam tshuam los ntawm noo noo, hmoov xim darkens, clumps thiab ua nyuaj. Thaum muaj kev cuam tshuam loj heev los ntawm kev ya raws, nws yuav ua tau nplaum thiab yaj, ua rau txo qis purity thiab nce ntxiv ntawm cov khoom muaj feem xyuam, uas cuam tshuam rau cov khoom zoo. Nyob rau hauv ntev - lub sij hawm ncaj qha raug rau lub teeb, cov khoom yuav maj mam degrade, maj mam tig daj nyob rau hauv cov xim thiab nce nyob rau hauv impurity cov ntsiab lus. Yog li ntawd, nws yog ib qho tsim nyog kom tsis txhob muaj kev tiv thaiv teeb pom kev thoob plaws hauv cov txheej txheem.
Solubility reference: soluble hauv organic solvents xws li methanol, ethanol, thiab dimethyl sulfoxide (DMSO); me ntsis soluble hauv dej; Yuav luag insoluble hauv non-polar solvents xws li n-hexane.
2, Cia txoj kev thiab ua kom tiav cov kev cai cia
1. Ib puag ncig khaws cia yooj yim
Nws yuav tsum tau muab cia rau hauv ib lub teeb shielded, kaw, txias, thiab qhuav ib puag ncig. Nws raug nquahu kom khaws qhov kub ntawm 15℃thiab 25℃rau ntev - lub sijhawm cia, thiab cov av noo ntawm ib puag ncig yuav tsum tswj qis dua 60%. Khaws kom deb ntawm qhov chaw sov, qhib nplaim taws, thiab tshav ntuj ncaj qha, thiab tsis txhob khaws cia rau hauv thaj chaw uas muaj qhov kub thiab txias sib txawv thiab lub hnub ci muaj zog xws li windowsills, boilers, thiab high - kub warehouses.
2. Ntim sealing yuav tsum
Cov ntaub ntawv raw yog ntim rau hauv hnab polyethylene kaw thiab ntim rau hauv lub tshuab nqus tsev aluminium foil hnab. Cov khoom ntim khoom ntim tau nruab nrog ob npaug - txheej tuab PE hnab hauv ob sab phlu, kaw nrog zip ties, thiab cov thawv ntawv sab nrauv yog tiv thaiv lub teeb; Tom qab qhib thiab siv, huab cua hauv lub hnab yuav tsum raug tshem tawm sai li sai tau, thiab lub foob yuav tsum tau nruj dua. Yog tias ua tau, lub tshuab nqus tsev sealing tuaj yeem siv rau kev sib khi thib ob txhawm rau txo kev sib cuag nrog huab cua thiab dej vapor thiab tiv thaiv kev nqus dej thiab degradation. Qhov chaw qhib mus ntev yog txwv tsis pub.
3. Cia thiab stacking qauv
Qhov chaw cia yuav tsum muaj qhov cua zoo, thiab nws raug nquahu kom tso cov dej noo- pov thawj cov tais rau hauv av. Nws yog txwv tsis pub cov khoom siv raw cov thoob / ntim cov hnab ntim ncaj qha rau hauv av kom tsis txhob ya raws los ntawm kev nkag mus rau hauv av thiab ua rau dampness. Cais cov khoom sib txawv ntawm cov khoom sib txawv, khaws ib daim ntawv teev npe zoo, thiab ua raws li thawj zaug hauv, thawj lub hauv paus ntsiab lus; Tsis txhob sib tov nrog cov kua qaub, cov hauv paus, oxidants, los yog volatile reagents kom tsis txhob muaj tshuaj lom neeg los yog kev sib kis.

Kev ua haujlwm siab ua kua chromatography txoj kev
1. Scope ntawm daim ntawv thov
Raw khoom purity xeem, loj - teev thawj zaug kuaj ntawm cov qauv matrix yooj yim; Cov zaub mov noj qab haus huv tsis yooj yim yog qhov ua rau muaj qhov tsis zoo, thiab cov qauv zoo yuav tsum raug kuaj xyuas los ntawm LC-MS/MS.
2. Kev ua haujlwm luv luv
Qauv methanol ultrasonic extraction, centrifugal pom; A C18 thim rov qab theem chromatography kem yog siv, nrog acetonitrile ammonium acetate tsis ntsev system feem ntau siv raws li theem mobile. UV nrhiav wavelength yog hais txog 223 nm, thiab kom muaj nuj nqis yog ua los ntawm cov txheej txheem sab nraud.
3. Kev txwv
Tsawg rhiab heev, tsis tuaj yeem paub qhov txawv ntawm cov qauv zoo sib xws, tsuas yog tsim nyog rau kev soj ntsuam cov qauv nrog cov ntsiab lus siab dua.

Peb lub tuam txhab tshwj xeeb hauv ntau yam kev poob phaus thiab slimming raw khoom. Txhawm rau pab txhawb cov neeg siv khoom cov qauv kev tshawb fawb thiab kev tsim kho, txheej txheem kev debugging, kev soj ntsuam zoo, thiab kev sim tshuab, peb txhawb cov neeg siv khoom siv cov qauv coj mus kuaj rau kev ntsuam xyuas ua ntej. Tag nrho cov qauv raug coj los ntawm cov txheej txheem tsim khoom, nrog rau kev ntim cov khoom tiav, ua kom ntseeg tau tias qhov zoo ntawm cov qauv me me zoo ib yam nrog cov khoom loj, thiab zam kev sib txawv batch uas yuav cuam tshuam rau kev tsim khoom tom ntej. Muab cov ntaub ntawv soj ntsuam ua tiav (COA) rau cov khoom no synchronously nrog cov qauv, uas qhia txog cov khoom zoo li, cov ntsiab lus purity, muaj feem xyuam rau cov khoom, ya raws, hnyav hlau, kab mob, thiab lwm yam kev xeem cov ntaub ntawv, ua tiav cov qauv, thiab coj mus kuaj txoj kev. Cov ntaub ntawv yog ua kom tiav thiab traceable, ua tau raws li tus neeg siv khoom qhov kev soj ntsuam zoo, kev kuaj xyuas, kev tshuaj xyuas cov ntaub ntawv thiab lwm yam kev xav tau. Thaum lub sij hawm ntsuam xyuas tus qauv, peb cov neeg ua hauj lwm muaj peev xwm pab teb cov lus nug ntsig txog cov khoom siv raw khoom, cov khoom siv lub cev thiab tshuaj lom neeg, thiab ua ntej - cov phiaj xwm kho mob. Tom qab lees paub tias qhov zoo ntawm cov neeg siv khoom kuaj ua tau raws li cov qauv, kev sib koom ua lag luam tuaj yeem sib tham. Rau kev txiav txim ntau, cov ntaub ntawv soj ntsuam zoo ntawm lub Hoobkas yuav raug muab batch los ntawm batch, txhawb kev koom tes kos npe thiab ua raws li daim ntawv xa nyiaj. Cov khoom zoo yuav raug tswj nruj nruj thoob plaws hauv cov txheej txheem los xyuas kom meej cov khoom ruaj khov. Tag nrho cov ntaub ntawv raw tsuas yog tso cai rau siv raws li cov xwm txheej uas tau tso cai los ntawm cov cai thiab cov cai. Tus neeg yuav khoom yuav tsum lees paub ntawm lawv tus kheej tias kev siv cov khoom siv raw ua raws li cov kev cai hauv lub tebchaws

Los ntawm kev xaiv koom tes nrog peb lub tuam txhab, koj tuaj yeem tsis tsuas yog tau txais cov khoom lag luam zoo raw khoom, tab sis kuj txaus siab rau ib qho - nres cov kev pabcuam kev pabcuam. Peb lub tuam txhab tau koom tes nrog kev lag luam ntawm cov khoom siv raw khoom rau ntau xyoo, nrog cov khoom lag luam paub tab thiab ruaj khov. Peb nruj me ntsis tswj lub Hoobkas zoo ntawm txhua batch ntawm cov khoom, tsim ib tug ua tiav tswj txheej txheem los ntawm raw khoom ntau lawm, ntim zoo soj ntsuam mus rau warehousing logistics, thiab ua tiav batch stability thiab controllable indicators. Txhua yam khoom tuaj yeem muab cov ntaub ntawv soj ntsuam zoo sib xws (COA), nrog rau cov ntaub ntawv ua tiav. Cov khoom lag luam ntau, ib txwm nyob hauv Tshuag, feem ntau cov lus qhia tshwj xeeb tuaj yeem npaj sai sai rau cov khoom xa tuaj yam tsis xav tau lub sijhawm tos ntev rau kev teem sijhawm ntau lawm. Kev tswj cov khoom lag luam paub tab kom paub meej cov khoom ruaj khov, tuaj yeem teb tau zoo rau cov neeg siv khoom xav tau, thiab ua kom luv luv. Tom qab qhov kev txiav txim tau lees paub, peb tam sim ntawd xyuas cov khoom muag, npaj rau kev ntim khoom thiab tawm mus, ua raws cov ntaub ntawv logistics thoob plaws hauv cov txheej txheem, synchronize cov xwm txheej thauj khoom raws sijhawm, thiab xyuas kom cov khoom xa tuaj raws sijhawm. Nyob rau tib lub sijhawm, cov khoom lag luam zoo yog tswj hwm nruj, thiab cov qauv kuaj thiab cov ntaub ntawv soj ntsuam zoo sib xws tuaj yeem muab tau. Kev txhawb nqa tom qab- kev muag khoom tiav, cov khoom siv tau zoo, cov khoom siv tau ruaj khov thiab txhim khu kev qha, thiab nws pab cov neeg siv khoom kom ua tiav cov haujlwm zoo yam tsis muaj kev ncua sijhawm tshawb fawb thiab kev tsim kho thiab kev tsim khoom.

1. Rau cov khoom lag luam zoo ib yam, yuav tsum muaj qhov tseem ceeb rau cov tsheb thauj khoom tsawg dua li cov tsheb thauj khoom thauj khoom thauj khoom, uas tsim nyog rau cov khoom siv raw khoom loj, nrog tus nqi siab - ua haujlwm tau zoo thiab muaj peev xwm nqa tau.
2. Rau cov qauv me me thiab cov khoom me me, kev xa khoom hauv tsev tuaj yeem xaiv tau sai thiab qhov rooj - mus rau - qhov rooj xa khoom.
3. Rau kev txiav txim sai, cov tsheb tshwj xeeb tuaj yeem npaj rau kev xa khoom ncaj qha kom txo lub sijhawm thauj mus los thiab ua kom cov khoom xa tuaj sai.
4. Rau ntev - cov khoom nyob deb hla lub xeev, siv lub hauv paus rau kev thauj mus los los txo cov kev thauj mus los thiab txo qhov kev pheej hmoo ntawm cov khoom thauj.
5. Yog tias yuav tsum muaj kev thauj mus los tshwj xeeb xws li cov hlua txias, kev zam lub teeb, thiab kev tiv thaiv kev ya raws, yuav tsum tau ua raws li kev thauj mus los uas muaj peev xwm tswj tau qhov kub thiab txias.
6. Txhawb cov neeg siv khoom kom qhia txog kev sib koom tes hauv kev sib koom tes, thiab peb lub tuam txhab yuav koom tes ua kom tiav cov ntim khoom xa tuaj thiab muab cov ntaub ntawv xa khoom cuam tshuam.
7. Kev txiav txim txawv teb chaws tuaj yeem npaj tau nrog kev thauj khoom hiav txwv, huab cua freight, kev thauj mus los thoob ntiaj teb, thiab kev pabcuam hauv kev tswj hwm kev lis kev cai tshaj tawm cov ntaub ntawv txhawb nqa.
8. Kev txiav txim luv luv hauv zos thiab nyob ze txhawb nqa tus kheej, thiab kev xa khoom luv luv kuj tuaj yeem npaj rau kev xa khoom yooj yim.
9. Cov tshuaj tswj tshwj xeeb yuav tsum raug thauj los ntawm cov tuam txhab logistics uas muaj kev phom sij rau kev thauj mus los raws li kev cai hauv tebchaws.

Peb lub tuam txhab ib txwm ua raws li kev lag luam lub tswv yim ntawm "kev ua tau zoo ua ntej, kev pabcuam thawj zaug, kev ncaj ncees thiab yeej- yeej", tsim kom muaj kev qhia dav dav, tus qauv thiab tag nrho- puag ncig tom qab- muag kev pabcuam lav qhov system, thiab lav tag nrho cov cai raug cai thiab kev txaus siab ntawm txhua tus neeg siv khoom, muab kev ruaj ntseg thiab txhim khu kev qha kev pabcuam rau cov neeg siv khoom tsim khoom, kev tshawb fawb thiab kev tsim kho tag nrho. Tag nrho cov khoom tawm hauv lub Hoobkas tau raug tshuaj xyuas nruj, thiab txhua pawg ntawm cov khoom tuaj yeem muab cov ntaub ntawv soj ntsuam zoo thiab ua tau zoo. Cov ntaub ntawv khoom muaj tseeb thiab ua tiav, thiab qhov zoo tuaj yeem taug qab los xyuas kom ruaj khov thiab mus txog tus qauv xa khoom zoo.
Nyob rau hauv tus txheej txheem ntawm kev xa khoom, peb lub tuam txhab tau nruab nrog kev mob siab rau tom qab - cov neeg ua haujlwm muag muag los soj ntsuam cov kev ua tiav ntawm kev txiav txim, warehouses thiab stocking, ntim thiab outbound, thiab logistics tsheb thauj mus los dynamics thoob plaws hauv tus txheej txheem. Peb lub sijhawm synchronize shipping cov ntaub ntawv, logistics taug qab cov lej, thiab kwv yees lub sijhawm tuaj txog nrog cov neeg siv khoom, daws cov teeb meem zoo xws li cov neeg siv khoom xa khoom nug thiab kev nug txog kev nce qib. Lub tuam txhab tswj hwm cov khoom lag luam txaus txaus, nrog rau kev txiav txim siab ceev ceev thiab kev xa khoom siab, kom ntseeg tau cov neeg siv khoom ntau tshaj plaws yam tsis muaj kev ncua sijhawm rau cov neeg siv khoom sim kev tshawb fawb thiab kev tsim kho thiab kev tsim khoom loj.
Tom qab tau txais cov khoom, yog tias muaj cov xwm txheej txawv txav xws li kev ntim khoom puas tsuaj, khoom tsis txaus, kev thauj mus los, lossis kev tsis sib xws ntawm cov qauv ntawm lub cev thiab cov khoom siv, cov neeg siv khoom tsuas yog yuav tsum muab cov ntawv pov thawj cuam tshuam raws sijhawm. Peb yuav teb sai sai, txheeb xyuas thiab daws lawv, thiab muab cov kev daws teeb meem dawb xws li hloov pauv, hloov pauv, sib tham thiab them nyiaj kom daws tau zoo thiab daws teeb meem tom qab- teeb meem muag. Nyob rau tib lub sijhawm, peb muab cov kev pabcuam kev cob qhia kev cob qhia ua haujlwm ntev, uas tuaj yeem teb cov neeg siv khoom cov lus nug txog cov txheej txheem cia khoom, kev ceev faj txog kev siv, kev siv tsis zoo, thiab muab kev txhawb nqa thoob plaws hauv cov txheej txheem.
Peb lub tuam txhab ua raws li tus qauv tsim tom qab- cov txheej txheem muag khoom, tsis kam ncua sijhawm, thiab mob siab rau muab kev saib xyuas ua ntej- muag, muag, thiab tom qab- kev muag khoom thoob plaws hauv tag nrho cov txheej txheem. Kev ceeb toom zoo: Cov khoom yuav tsum tau muab khaws cia rau hauv qhov tsaus ntuj, kaw, thiab qhuav qhov chaw raws li tus qauv txheej txheem. Cov teeb meem zoo tshwm sim los ntawm kev cia khoom tsis raug, ntim tsis raug cai, lossis kev siv tsis raug cai los ntawm cov neeg siv khoom yuav tsis raug them los ntawm tom qab - muag lav. Peb siv zog los tiv thaiv txhua tus neeg siv khoom nrog kev ruaj ntseg zoo, kev pabcuam zoo, thiab kev ua haujlwm ncaj ncees

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