Florfenicol yog ib qho hluavtaws monofluorinated derivative ntawm thiamphenicol. Nws cov mis molecular yog C12H14Cl2FNO4S. Nws nthuav tawm raws li dawb los yog tawm -dawb crystalline hmoov uas tsis muaj ntxhiab; Nws yog me ntsis soluble hauv dej thiab chloroform, me ntsis soluble hauv glacial acetic acid, thiab soluble hauv methanol thiab ethanol. Nws yog ib qho tshiab, dav -spectrum antibacterial tus neeg sawv cev ntawm chav kawm chloramphenicol, tsim tshwj xeeb rau cov kws kho tsiaj siv thaum xyoo 1980s.
Nws yog thawj zaug launched nyob rau hauv Nyiv nyob rau hauv 1990. Nyob rau hauv 1993, Norway tau pom zoo cov tshuaj rau kev kho mob ntawm furunculosis nyob rau hauv salmon. Xyoo 1995, Fab Kis, United Kingdom, Austria, Mexico, thiab Spain tau pom zoo siv los kho cov kab mob ua pa hauv nyuj. Nyob rau hauv Nyiv thiab Mexico, nws kuj tau pom zoo raws li ib tug pub additive rau swine los tiv thaiv thiab kho cov kab mob; cov tshuaj twb tau pom zoo siv rau hauv kuv lub teb chaws thiab.
Florfenicol yog ib qho tshuaj tua kab mob uas ua rau dav -spectrum bacteriostatic nyhuv los ntawm inhibiting peptidyl transferase kev ua. Nws cov kab mob tua kab mob yog qhov dav, suav nrog ntau yam Gram-zoo thiab Gram- cov kab mob tsis zoo, nrog rau mycoplasmas. Cov kab mob ua rau muaj xws li * Haemophilus * hom (hauv nyuj thiab npua), * Shigella dysenteriae *, * Salmonella * hom, * Escherichia coli *, * Streptococcus pneumoniae *, * Haemophilus influenzae *, * Streptococcus * hom, * Staureusphyloco * * Leptospira *, * Rickettsia *, thiab lwm yam. Vim nws lipophilicity, cov khoom no tau nkag mus rau hauv cov kab mob hlwb. Nws feem ntau ua rau 50S subunit ntawm cov kab mob 70S ribosome, inhibiting transpeptidase kev ua; Qhov no impedes peptide saw elongation, yog li thaiv peptide daim ntawv cog lus tsim thiab thaum kawg inhibiting protein synthesis kom ua tiav nws cov nyhuv antibacterial. Ua raws li kev tswj hwm qhov ncauj, cov khoom tau nrawm nrawm thiab nthuav dav thoob plaws hauv lub cev; nws yog tus cwj pwm los ntawm ib nrab ntev - lub neej, ua rau cov ntshav siab tshuaj ntau ntxiv uas tau txhawb nqa lub sijhawm ntev.
