Henan Jinyi tsuas yog tsim thiab muag cov khoom siv tshuaj raw khoom sibutramine, uas yog kev noj qab haus huv suppressing raw khoom; Nws feem ntau ua haujlwm los ntawm nws cov amine (thib ob thiab thawj amine) metabolites, thiab nws lub ntsiab mechanism yog inhibit qhov reuptake ntawm norepinephrine, serotonin, thiab dopamine los txhim kho satiety. Nws cov tsos yog dawb crystalline hmoov, uas tuaj yeem ua rau kom satiety, txo kev tshaib kev nqhis, hlawv rog, txhim kho cov metabolism, tshem tawm cov zaub mov ntau hauv lub cev, ua kom poob phaus sai, thiab daws qhov teeb meem ntawm kev noj ntau dhau thiab rog.
| Suav npe | Sibutramine |
| Suav alias | N - (1- (1- (4-chlorophenyl) cyclobutyl) -3-methylbutyl) - N, N-dimethylamine |
| English npe | Sibutramine |
| CAS nr | 106650-56-0 |
| Cov mis mos molecular | C17H26ClN |
| Molecular hnyav | 279.85 |
| Qhov tseeb zoo | 279.17500 |
| PSA | 3.24000 |
| LogP | 4.73800 |
| Qhov tshwm sim | Dawb crystalline hmoov |
| Melting point | 191-192 ° C |
| Molar refractive index | 83.76 |
| Molar ntim (cm3 / mol) | 271.3 |
| Tos Zhang Biarong (90.2K) | 670.5 |
| Nto nro (dyne / cm) | 373.3 |
| Polarization tus nqi (10-24cm3) | 33.2 |
| Ib leeg isotope mass | 279.175378 Ib |
| Nominal loj | 279 ua |
| Qhov nruab nrab zoo | 279.848 ib |
| Tus nqi siv rau hydrophobic parameter xam (XlogP) | 5.4 |
| Tus naj npawb ntawm hydrogen bond pub | 0 |
| Tus naj npawb ntawm hydrogen bond acceptors | 1 |
| Number of rotatable chemical bonds | 5 |
| Tus naj npawb ntawm tautomers | 0 |
| Topological molecular polarity nto cheeb tsam | 3.2 |
| Tus naj npawb ntawm cov atom hnyav | 19 |
| Nto nqi | 0 |
| nyuaj | 275 |
| Tus naj npawb ntawm isotopic atoms | 0 |
| Txiav txim seb tus naj npawb ntawm atomic stereocenters | 0 |
| Tsis paub tus naj npawb ntawm atomic stereocenters | 1 |
| Txiav txim seb tus naj npawb ntawm cov chemical bond stereocenters | 0 |
| Tus naj npawb ntawm cov tshuaj tsis paub tseeb stereocenters | 0 |
| Number of covalent bond units | 1 |
| lub sijhawm lav zoo | 24 hli |
| Txoj kev txuag nyiaj | qhov chaw txias thiab qhuav |
Cov lus nug thiab lus teb nquag
Q: Dab tsi yog qhov purity ntawm sibutramine?
Teb: Sibutramine muaj purity ntau dua 99% thiab tuaj yeem muab cov ntaub ntawv kuaj COA, siab -kev ua haujlwm ua kua chromatography (HPLC) kev soj ntsuam, thiab thib peb- cov ntaub ntawv kuaj xyuas tog, xws li SGS kuaj ua los ntawm Shanghai cov chaw sim.
Lus Nug: Dab tsi yog qhov tsos ntawm sibutramine?
Teb: Dawb crystalline hmoov los yog hmoov dawb.
Q: Lub luag haujlwm tseem ceeb thiab kev siv ntawm sibutramine yog dab tsi?
Teb: Sibutramine feem ntau inhibits qab los noj mov, nce satiety, tswj kev noj zaub mov, hlawv rog, thiab txhawb cov metabolism. Feem ntau yog siv rau formulations, ntsiav tshuaj candies, poob phaus kas fes, thiab kev tshawb fawb thiab kev loj hlob ntawm cov khoom tshiab rau cov tuam txhab tshuaj.
Q: Puas muaj qhov ua tau zoo ntawm kev tswj qhov hnyav
Teb: Yog, daim duab yog raws li nram no
Cov kev cai zoo rau sibutramine
1. Cov tsos mob: Cov khoom no yog dawb los yog tawm dawb crystalline hmoov; Yooj yim rau yaj hauv methanol thiab ethanol, me ntsis soluble hauv dej.
2. Kev txheeb xyuas: Infrared spectrophotometric yuav tsum tau siv, thiab infrared absorption spectrum yuav tsum ua raws li cov ntaub ntawv siv spectrum; Lub sijhawm khaws cia ntawm lub ntsiab ncov ntawm cov qauv ntsuas hauv cov kua chromatography yuav tsum ua raws li cov qauv siv.
3. Acidity: Dissolve 0.1g hauv 20ml dej, pH 4.0-6.0.
4. Cov khoom muaj feem xyuam: Kev ua haujlwm siab ua kua chromatography, nrog rau tus kheej impurities tsis tshaj 0.5% thiab tag nrho impurities tsis tshaj 1.0%.
5. Kev txiav txim siab txog cov ntsiab lus: HPLC tus qauv txheej txheem sab nraud, suav tias yog cov khoom tsis muaj dej, cov ntsiab lus yuav tsum nyob nruab nrab ntawm 98.0% thiab 102.0%.
6. Cov ntsiab lus noo noo: 5.0% -6.5% (monohydrate).
7. Hlawv residue: tsis pub tshaj 0.1%.
8. Cov hlau hnyav: Tag nrho cov kev txwv ntawm cov hlau hnyav xws li txhuas, cadmium, mercury, arsenic, thiab lwm yam yog tsawg dua lossis sib npaug li 10ppm.
9. Cov kuab tshuaj residual: Cov kuab tshuaj nyob hauv cov organic xws li methanol, ethanol, thiab dichloromethane ua tau raws li cov cai txwv ntawm cov cai ntawm pharmacopoeia.
Vim li cas thiaj xaiv peb
1. High purity thiab ruaj khov zoo: Cov khoom purity yog nruj me ntsis tswj, qhov taw qhia ntawm batches yog ruaj khov, impurities yog tswj nyob rau hauv qhov chaw, thiab downstream siv cov nyhuv yog guaranteed, nrog tsawg heev zoo fluctuations.
2. Txoj kev xeem ntawv tso cai: Cov txheej txheem kev xeem kws tshaj lij yog siv los ua pov thawj batch, thiab cov ntaub ntawv kuaj COA tuaj yeem muab tau. Cov ntaub ntawv yog qhov tseeb thiab traceable, thiab tag nrho cov ntsuas yog raws li cov pov thawj.
3. Cov khoom lag luam tsim nyog: Khaws cov khoom lag luam ntau ntawm tes, tsis tas yuav tsum tau tos lub sijhawm ntev, tuaj yeem npaj cov khoom xa tuaj sai, yoog raws cov neeg siv khoom xaj sijhawm, thiab tuaj yeem koom tes nrog kev txiav txim sai.
4. Kev kuaj tus kheej muaj peev xwm: nruab nrog nws tus kheej lub chaw kuaj mob, nws tuaj yeem ua cov qauv kuaj, tshuaj xyuas kev ua haujlwm zoo, tsis tu ncua ua kom zoo dua cov khoom, thiab koom tes nrog cov neeg siv khoom los ua qhov cuam tshuam cov khoom siv.
Kev ntim khoom, kev thauj mus los, thiab kev thaij duab hauv tsev
Ntim Specifications
25kg / cardboard nruas, lined nrog ob - txheej PE hnab; Cov qauv hnyav nruab nrab ntawm 100g thiab 1kg yog ntim rau hauv cov hnab aluminium foil nqus tsev vacuum, kaw thiab khaws cia deb ntawm lub teeb.
tsheb thauj mus los
Kev thauj los ntawm av lossis dej hiav txwv, thiab txhawb nqa thiab tiv thaiv cov khoom ntim sab nraud thaum thauj mus los kom tsis txhob raug tshav ntuj, nag, compression, thiab kev sib tsoo; Cov khoom yuav tsum yog noo noo- pov thawj thiab lub teeb pov thawj, thiab daim ntawv qhia txog kev tshuaj xyuas COA yuav tsum txuas nrog rau kev xa khoom ntawm cov khoom; Yog tias muaj kev puas tsuaj thaum lub sij hawm xa khoom, thov thaij duab thiab muab cov lus tawm tswv yim raws sijhawm.
Muaj txaus
Lub Hoobkas muaj peev xwm tsim tau ruaj khov thiab muaj nws lub tsev rau khoom nrog cov khoom npaj txhij, uas tuaj yeem ua rau ob qho me me ntawm cov qauv thiab xaj loj. Nws tseem tuaj yeem ua kom cov khoom tsis tu ncua thaum lub caij nyoog siab tshaj plaws, nrog rau cov khoom xa tuaj yeem tswj tau, kom tsis txhob muaj kev pheej hmoo ntawm cov khoom lag luam.
Tom qab - kev muag khoom
Kev sib txuas lus ua ntej muag
Ua ntej kev muag khoom, peb tuaj yeem sib txuas lus ib qho - ntawm - ib qho nrog cov neeg siv khoom thiab muab 100 grams cov qauv dawb rau cov neeg siv khoom kuaj. Tom qab cov khoom zoo ua tau raws li cov qauv, peb tuaj yeem sib tham txog kev koom tes.
Kev sib txuas lus thaum muag
Ua tib zoo sib txuas lus nrog cov neeg siv khoom, daws lawv cov lus nug, koom tes nrog lawv cov kev xav tau, ua siab ntev mloog lawv cov kev xav tau, teb sai sai rau kev tawm tswv yim, nquag sib txuas lus thiab ua raws li kev nce qib, thiab tswj kev sib raug zoo nrog kev mob siab rau.
Tom qab - kev muag khoom
koj tsis txaus siab rau cov khoom zoo tom qab tau txais cov khoom thiab lub ntim puas thaum lub sij hawm shipping, peb lub tuam txhab tuaj yeem xa rov qab los yog muab tag nrho cov nyiaj rov qab thiab them nyiaj. Ua kom yooj yim tom qab- txheej txheem muag khoom thoob plaws tag nrho cov txheej txheem, tsis tas yuav tsum muaj cov txheej txheem nyuaj, thiab teb rau cov neeg siv khoom xav tau raws sijhawm, ua rau koj qhov kev yuav khoom tsis muaj kev txhawj xeeb thiab kev koom tes ruaj ntseg dua.
Cim npe nrov: Tuam Tshoj sibutramine raw khoom manufacturers, lwm tus neeg, Hoobkas
